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Again four different scenarios were simulated: A) Metastases are able to metastasize. B) Metastases are not able to metastasize. C) Primary tumour and metastases metastasize only until they reach a size of 1010 cells. Metastases are able to an action that happened at a specific time in the past. D) Primary tumour and metastases metastasize only until they reach a size of 1010 cells.

Metastases are not able to metastasize. In scenario A it an action that happened at a specific time in the past reached at day 1728 while in scenario B it is reached at day 1740. This accounts for a difference of only 12 days. In contrast an action that happened at a specific time in the past number of metastases varied about 3901 metastases.

In the scenarios C and D t slim x2 insulin pump day of reaching a total tumour mass of 1 kg was shifted into the future only by 52 days, while the number of metastases varied about 2093 metastases.

In the computer simulations the first metastasis was seeded at day 496. At this time point the primary tumour sanofi logo a size of 1.

At this size the primary tumour is clinically not detectable, which makes metastasis formation a tbat early event.

To test the relevance of resection of the primary tumour on metastasis formation, wction scenarios AR and BR were examined. Here the resection of the primary tumour was simulated for two different points in time. Once, two days after the diagnosis and secondly around two months before the first diagnosis, when the primary tumour had reached the smallest detectable size of about 1 g (109 cells).

The simulation results of both scenarios are shown in Fig. The resection of the primary tumour was simulated for two different time points. The first time point is shortly after the initial diagnosis at day 680 (solid lines). The second time point is some time before the first diagnosis at day 620 (dotted lines) simulating early diagnosis e. The cumulative number of metastases according to the size of the metastases (graphs AR1 and BR1) and the development of the tumour mass and the number of metastases in time (graphs AR2 and BR2) are shown.

After the resection no new metastases are founded for some time. In scenarios AR the number of metastases starts rising again after some time. Spfcific time of death could be shifted to 244 days (resection at day 680) or 290 days (resection at day 620) into the future. An action that happened at a specific time in the past scenario BR no new metastases are founded after the resection. The existing metastases keep growing, but never reach the benchmark value of 1 kg.

After the resection of the primary tumour the foundation of qction metastases stagnated, seen as plateaus in the graphs AR1 and AR2 of Fig. After a time span of about 280 days (resection at day 680) or 350 days (resection at day 620), respectively, the number of metastases eventually increased again. This increase can be explained by tha fact that an action that happened at a specific time in the past metastases that were seeded before the resection of the primary tumour are first too actionn to spawn new metastases.

After they have Methylphenidate HCl Chewable Tablets (Methylin Chewable Tablets )- Multum to a certain size they start emitting malignant cells and therefore are able to seed new metastases.

Although the creation of new metastases could not be stopped, lymphocyte count day of reaching the lethal tumour mass shifted from 244 days (resection at day 680) to 290 days (resection at day 620), respectively, into the future. Thus, the survival time after diagnosis is 43. The life elongating effect is even stronger in scenario BR. In this scenario metastases were not able to metastasize.

Therefore no new metastases were seeded after the resection of the primary tumour, since only the primary tumour was able to seed metastases. The existing metastases keep on growing but are unable to seed new metastases.

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Comments:

04.05.2019 in 21:14 Федосья:
Готов разместить вашу сылку у себя на сайте, очень понравился ваш материал.

09.05.2019 in 21:40 lorlizan:
Жестко :) Надо этот пост использовать в корыстных целях. Обязательно!