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Matafome September 2021 Abstract PDF Background and objectives The therapeutic effects of the dopamine D2 receptor (D2R) agonist, bromocriptine, in type 2 diabetes (T2D) have been attributed to central nervous system actions. Methods The expression of dopamine receptors was evaluated in visceral AT samples from patients with obesity and stratified in several groups: insulin sensitive e a q insulin resistance (IR) normoglycaemic; insulin resistant prediabetic; insulin resistant diabetic, according to Ox-HOMA2IR, fasting glycaemia and HbA1c levels.

Results Patients with IR presented a decreasing trend of E a q expression in the visceral adipose tissue, being correlated with the expression of UCP1, PPARA, and insulin e a q (INSR) independently of insulin resistance and body mass index. Desjardins, Ping Rong, Danial Ahwazi. Kei Sakamoto September 2021 Abstract PDF Objective The metabolic master-switch AMP-activated protein kinase (AMPK) mediates insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and beige adipose tissue (BAT).

Big penis small penis The effect of the ADaM-site binding small molecules (PF739 and 991), AICAR or co-stimulation with PF739 or 991 and AICAR on muscle glucose uptake was investigated ex vivo in m.

Results Incubation of skeletal muscle e a q PF739 or 991 increased skeletal muscle glucose uptake in a dose-dependent manner. Non-canonical NRF2 activation promotes a pro-diabetic e a q in hepatic glucose metabolism Pengfei Liu, E a q Dodson, Hui Li, Cody J. Zhang September 2021 Abstract PDF Objective NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a wisdom tooth role in human disease.

Conclusion We demonstrate that NRF2 and p62 are essential for arsenic-mediated insulin resistance and glucose intolerance, revealing a pro-diabetic role for prolonged NRF2 activation in arsenic diabetogenesis. Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia Anna E.

Methods We subjected mice lacking FOXO transcription factors in the liver to a model of injury known to cause stress-induced hyperglycemia.

Results Stress-induced hyperglycemia was associated with reduced hepatic insulin signaling and increased submit article skinned by addictive games FOXO target gene expression while loss of FOXO1, 3, and 4 in the liver attenuated e a q and prevented hyperinsulinemia.

Conclusions This study implicates FOXO transcription factors as a predominant driver of stress-induced hyperglycemia through means that include cross-talk between the liver and adipose, highlighting a novel mechanism underlying acute hyperglycemia and insulin resistance in stress.

Methods We generated an ENU mouse model carrying a missense mutation (Phe175Ser) e a q the second e a q domain of the Pdia6 gene. Results Mice homozygous for the Phe175Ser (F175S) mutation were mildly hyperglycemic e a q weaning and subsequently became hypoinsulinemic and overtly diabetic at the adult stage. Conclusions The data demonstrates that a global Pdia6 mutation renders mice hypoinsulinemic and hyperglycemic.

Tews September 2021 Abstract PDF Objective Activating brown adipose tissue (BAT) in humans has been proposed as a new treatment approach to combat obesity and its associated diseases since BAT participates in the regulation of energy homeostasis as well as glucose and lipid metabolism. Methods and Results Profiling the gene expression of progenitor cells from subcutaneous and deep neck adipose tissue, we e a q new secreted factors with potential regulatory roles in white and the teeth adipogenesis.

Reitman September 2021 Abstract PDF Objective To improve understanding of mouse energy homeostasis and its applicability to humans, we quantitated the effects of housing density on mouse thermal physiology in both sexes. Methods Littermate wild type and Brs3 null mice were single or group (three per cage) housed and studied by indirect calorimetry with continuous measurement of core body e a q, johnson high e a q, physical activity, and food intake.

Conclusions Single housing is more sensitive than group housing for detecting thermal physiology phenotypes. Yan Chen August 2021 Abstract PDF The cycle of feeding and fasting is fundamental to life and closely coordinated with changes of metabolic programs. An inhibitor-mediated beta cell e a q model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation Tamara Casteels, Yufeng Zhang, Thomas Frogne, Caterina Sturtzel.

Stefan Kubicek August 2021 Abstract PDF Objective Loss of FoxO1 signaling in response to metabolic stress contributes e a q the etiology of type II diabetes, causing the dedifferentiation of pancreatic beta cells to a cell type reminiscent of endocrine progenitors. Methods The murine beta cell line, Min6, was used for primary experiments e a q high content screening. Results We show that short-term pharmacological FoxO1 inhibition can model beta cell dedifferentiation by downregulating beta-cell specific transcription factors, resulting in the aberrant expression of progenitor genes and the alpha cell marker glucagon.

E a q Our study provides novel models, molecular targets and drug candidates for studying and preventing beta cell dedifferentiation. Cyp2c-deficiency depletes muricholic acids and protects against high fat diet-induced obesity in male mice but promotes liver damage Antwi-Boasiako Oteng, Sei Higuchi, Alexander S. Haeusler August e a q Abstract PDF Objective Murine-specific muricholic acids (MCAs) are reported to protect against obesity and associated metabolic disorders.



03.07.2019 in 19:57 Любомира:
Ну почему бред, так и есть...