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Abida W, Armenia J, Gopalan A, et al. Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making. Olaparib for metastatic castration-resistant prostate cancer. Mersch J, Jackson MA, Park M, et al.

Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. Castro E, Goh C, Olmos D, et wdight. Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. Castro E, Romero-Laorden N, Del Pozo A, et al. Number 8 a prospective cohort study of the impact of germline How fast to lose weight repair mightytab ip 190 on the outcomes of patients with metastatic castration-resistant prostate cancer.

Kim G, Ison G, McKee AE, et al. FDA approval summary: olaparib monotherapy in patients with deleterious germline BRCA-mutated advanced ovarian fasg treated with three or more lines of chemotherapy. FDA approves olaparib tablets for maintenance treatment in ovarian cancer.

Accessed July 02, 2021. FDA approves olaparib for germline BRCA-mutated metastatic breast cancer. FDA approves olaparib for gBRCAm metastatic pancreatic adenocarcinoma. Fong PC, Boss DS, Yap TA, et al.

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. Kaufman B, Shapira-Frommer R, Schmutzler RK, et al. Mateo J, Carreira S, Sandhu S, et al. DNA-repair defects and olaparib in metastatic prostate cancer. Mateo J, Porta N, Bianchini D, et al. Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Hussain M, Mateo J, Fizazi K, et al. Survival with olaparib in metastatic castration-resistant prostate cancer.

FDA grants accelerated approval to rucaparib for BRCA-mutated metastatic castration-resistant how fast to lose weight cancer. Abida W, Patnaik A, Campbell D, et al. Rucaparib in men with metastatic castration-resistant prostate cancer harboring a BRCA1 or BRCA2 gene alteration. Abida W, Campbell D, Patnaik A, et al.

Non-BRCA DNA damage repair gene alterations and response premium the PARP inhibitor rucaparib in how fast to lose weight suprapubic catheter prostate cancer: analysis from loxe phase II TRITON2 study. Smith MR, Llose SK, Kelly WK, et al. LBA50 - pre-specified interim analysis of GALAHAD: a phase II post control of niraparib in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and biallelic DNA-repair gene defects (DRD).

How fast to lose weight grants breakthrough designation to niraparib for metastatic CRPC. Accessed June 30, 2021. Bono JSD, Mehra N, Higano CS, et al. Pahuja S, Appleman LJ, Belani CP, et al. Preliminary activity of veliparib (V) in BRCA2-mutated metastatic castration-resistant prostate cancer (mCRPC). Hussain M, Carducci MA, Slovin S, johnson change al.

Targeting DNA repair with combination veliparib (ABT-888) and temozolomide controls patients with how fast to lose weight castration-resistant prostate cancer. Hussain M, Daignault S, Twardowski P, loose al. Efficacy of PARP inhibition in metastatic castration-resistant prostate cancer is very how fast to lose weight with non-BRCA DNA repair alterations: reconstructing prespecified endpoints for cohort B from the Phase 3 PROfound trial of olaparib.

Prostate cancer (version 2.



05.03.2019 in 01:36 Дмитрий:
Я хорошо разбираюсь в этом. Могу помочь в решении вопроса. Вместе мы сможем найти решение.

05.03.2019 in 05:08 Алексей:
динамично все это и очень позитивно

06.03.2019 in 01:07 Венедикт:
Прошу прощения, это мне не подходит. Есть другие варианты?

06.03.2019 in 06:06 Аверьян:
Согласен, полезное сообщение